Objective The purposes of this study was to investigate the curative effect difference of periapical cyst on anterior teeth treated by root canal therapy and root canal therapy combined apicectomy. Methods The study included clinical cases with periapical cysts on 91 anterior teeth that were treated by root canal therapy. These teeth were randomly assigned to two groups. 44 teeth were treated by apicectomy as experimental group while 47 teeth as controls. All teeth were followed clinically and radiographically examinations for a period ranging from 3 months to 1 year. Results The results of experimental group showed 90.9％ success and the other group was 87.2% success. The difference was not significant（P＞0.05）. Conclusion Root canal therapy is effective in treating the anterior teeth with periapical cysts. Apicectomy should be done only when root canal therapy was ineffective.
