Non-syndromic cleft lip with or without cleft palate is a common birth defect. The relationship between cleft lip and palate and dermatoglyphic features is widely recognized, frequently studied, and poorly understood. We summarized a select group of articles on this topic, and discussed the current understanding of dermatoglyphic features in individuals with cleft and their parents, as well as the relative heredity diseases, oral diseases, epidemiology in this article.