A series of biochemical reaction happened in the periodontal tissue during orthodontic tooth movement, varies cytokine and hormone participate in the process. High mobility group protein box 1（HMGB1） is an important late inflammatory mediator. In recent years, researches have made to find that HMGB1 was involved in the remolding and metabolism of bone and can interacted with fibroblast. Because of the biological effect, we can speculate that HMGB1 may play an important role in the remolding of periodontal tissue during orthodontic tooth movement. This review focused on the relationship between HMGB1 and orthodontic tooth movement.
