Mitochondria are organelles in mammalian cells, with the only genetic material outside the nucleus mitochondrial DNA（mtDNA）. It supported and participated in many important cellular functions. MtDNA vulnerabled to a variety of factors and cause damage because of special structures and advancement of genetics. When mtDNA damage happened, some mtDNA repair factors, such as: Mitochondrial transcription factor A, mtDNA polymerase- γ, 8-oxoguanine DNA glycosylase enzymes take part in the damage repairing. The entire repair process were regulated by related factors.
