Objective To investigate the effect, complication and nursing key of tooth extraction under the monitoring of electrocardiogram. Methods 934 cases of tooth extraction accompanying with angiocardiopathy were treated under the monitoring of electrocardiogram. All the patients were nursed in all the management. Results Among the 934 cases, there was no any complication in 913 cases. There were some complications, such as high blood pressure, T wave changes, in 21 cases. Tooth extractions were finished after the patients had been given drugs and the symptom had disappeared. Conclusion Tooth extraction under the monitoring of electrocardiogram provides a safe and effective method for the patients of angiocardiopathy who need tooth extraction. Nursing is an important part of tooth extraction under the monitoring of electrocardiogram and helpful to decrease the danger of operation.