Objective To observe the effect of inhaling N2O(called laughing gas) superficial anesthesia accompanied by the chair video in combination with local anesthesia in patients undertaking dental implantation. Methods 60 patients undertaking dental implantation were selected and divided randomly into two groups(30 in each). The operations include bilateral maxillary sinus lift operation, onlay bone graft operation and operation of simultaneous placement of multiple implants. Adopt superficial anesthesia by inhaling N2O accompanied by the chair video in combination with local anesthesia for the experiment group and adopt local anesthesia for the control group. Changes in the heart rate and blood pressure were observed to evaluate differences in level of the pain tolerance and the sedation in two groups. Results The heart rate and blood pressure of control group were significantly higher than the patients in the experiment group. The level of sedation and the degree of pain tolerance in the control group were significantly lower than the patients in the experiment group. Conclusion Inhaling N2O superficial anesthesia accompanied by the chair video in combination with local anesthesia is safe and effective, which should be widely applied in dental implant.