CC类趋化因子受体7 及其配体与口腔鳞癌的关系
Study of relationship between expression of CC chemokine receptor 7 and its ligands and oral squamous cell carcinoma
作者：金鑫 王静 王芳综述 曾昕 陈谦明审校
Author：JIN Xin, WANG Jing, WANG Fang, ZENG Xin, CHEN Qian-ming.
收稿日期：2009-11-23 年卷（期）页码：2011,38(1):119-121
期刊名称：国际口腔医学杂志
Journal Name：International Journal of Stomatology
关键字：趋化因子, CC 类趋化因子受体7, 口腔鳞状细胞癌, 侵袭, 淋巴结转移,
Key words：chemokine, CC chemokine receptor 7, oral squamous cell carcinoma, invasion, lymph node metastasis,
基金项目：
国家自然科学基金资助项目（30772424，81072218）；四川省青年科技基金资助项目（09ZQ026-037）
中文摘要
趋化因子是一组具有趋化作用的细胞因子超家族，通过与特异性受体结合发挥生物学功能。趋化因子受体7 与口腔鳞癌的侵袭和淋巴结转移等密切相关，现就趋化因子受体7 及其配体的功能以及它们在口腔鳞癌侵袭和淋巴结转移中的作用作一综述。
英文摘要
Chemokines belong to the small molecule chemoattractive cytokine family. They are involved in diverse biological actions through combining with their specific receptors. Recent studies showed that the expression of CC chemokine receptor 7（CCR7） were significantly associated with the invasion and lymph node metastasis of oral squamous cell carcinoma（OSCC）. This review will concentrate on the functions of CCR7 and its ligands, and their effects in invasion and lymph node metastasis of OSCC.
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