The knowledge about cranio-maxillo-facial growth and development is an important part of orthodontic theories. People from different nations, regions, and genders have various patterns of craniofacial structure and occlusions, and the research about facial growth is complicated and difficult. Along with the advancement of technology, the studies on cranio-maxillo-facial growth develop from cross-sectional study to long-term longitudinal study, from 2-demensional to 3-demensional information acquisition. And the developing computer technique and software make the research more intensive. Such studies help our orthodontists to make precissive prediction of growth and clinic judgement. This topic is to overview the recent methods of studying cranio-maxillo-facial development.