The tooth extraction of patient who is long-time using of anticoagulant drug is regard as taboo by oral and maxillofacial surgeon. With the increasing level of health care and aging trends, oral and maxillofacial surgery clinics appear more and more such patients. However, people have different opinions on how to deal with such patients. Based on the related researches in recent years. This review strived for giving a comphrensive angle for this kind of patients from preoperative risk assessment, preoperative preparation, preoperative and postoperative risk.