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论文摘要

基因芯片技术在牙髓生物学研究中的应用进展

Research progress on gene chip technology and its applications in dental pulp biology

作者:龚启梅综述 凌均棨审校

Author:Gong Qimei, Ling Junqi.

收稿日期:2011-12-08          年卷(期)页码:2012,39(5):608-611

期刊名称:国际口腔医学杂志

Journal Name:International Journal of Stomatology

关键字:牙髓, 牙髓细胞, 基因芯片, 基因表达谱,

Key words:dental pulp, dental pulp cell, gene chip, gene expression profiles,

基金项目:

中文摘要

基因芯片作为一种高通量、快速和平行核酸序列测定及定量分析技术已经广泛地应用于分子生物学领域。牙髓基因组学的研究将有利于加强人们对牙髓生理和病理机制的认识,从而最终应用于临床预防、诊断和治疗等,因此,本文就基因芯片技术及其与牙髓干细胞相关的基因、牙髓老龄化改变相关的基因和龋病时牙髓相关的基因等研究进展作一综述。

英文摘要

Gene chip was a high-throughput, rapid, parallel nucleic acid sequence detection and quantitative analysis technology. It has been widely used in molecular biology in recent years. Study on dental pulp genomics will help to understand the physiological and pathological mechanisms of pulp, thus contributing to the clinical application in prevention, diagnosis and treatment. In this review, we briefly described the gene chip technology and its applications in dental pulp stem cells, aged dental pulp and dental caries.

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