Emdogain（EMD） is a product derived from developing enamel which contains various enamel matrix proteins and derivatives. It is believed to act as a tissue -healing modulator which helps stimulate periodontal regeneration, biomineralization and bone induction. Previous studies suggested that EMD contains various proteins, such as amelogenin, enamelin, ameloblastin, which might be involved in bone induction, angiogenic formation etc. Recently, growth-factor like activity has been observed in EMD which suggested that EMD might be used as another candidate out of growth factors in tissue engineering research. This review summarized the research progress on components and their individual effects of EMD to give an overview for further development of EMD applications.
