Lipoxin A4(LXA4) is one of the products of arachidonic acid metabolic pathway. It displays promising bioaction of anti-inflammatory, as well as pro-resolving. In this review, the author focus on the synthesis, function, and metabolism of lipoxin and the research development of LXA4 and its analogs, LXA4 and inflammatory, then to explore the possibilities of its application in oral mucosal disease research.