Atypical odontalgia（AO） is a kind of orofacial pain with undefined etiology and has certain connection with endodontic therapy. The sufferers tend to have persistent discomfort and decreased life quality. However, lack of knowledge on this condition often leads to misdiagnosis and mistherapy, adding to patients’physiological, psychological and economic burdens. This review article briefly summed up recent studies on the definition, diagnosis, differential diagnosis, physiological and pathological mechanism, clinical manifestation and therapeutic approaches of AO for reference in clinical practice.
