Objective To compare the bond durability of five self-adhesive resin cements to polished and sandblasted zirconia ceramic. Methods Zirconia ceramic samples were sintered and polished. Half of polished ceramic samples were sandblasted with 50 μm alumina particles. The roughness of polished and sandblasted zirconia ceramic surface was measured by 3D-laser scanning microscope. The polished and sandblasted ceramic samples were bonded to composite cylinders with either Biscem(BC), G-Cem(GC), RelyX U100(RU), Multilink Speed(MS) or Maxcem (MC). The samples divided into two subgroups to receive respectively shear test after 0 and 10 000 time thermal cycles. The data were analyzed by one-way ANOVA test and independent sample t test. Results Air abrasion significantly increased Ra of zirconia ceramic surface(P<0.001). Thermocycling decreased significantly the bond strengths of all test groups(P<0.001), in which polished specimens bonded with MS had significantly higher bond strength than those bonded with either BC, GC, RU, or MC(P<0.001), and air abrasion significantly increased the bond strength of BC, GC, RU and MC, whereas the bond strength of MS was not significantly affected by air abrasion. Conclusion The bond durability of different self-adhesive resin cements to zirconia ceramic has significant differences, and their bond durability was not completely influenced by air abrasion of ceramic surface.