Both osteoporosis and tooth loss are prevalent in the elderly population. Thus, implant use is essential in solving the problem of missing teeth in osteoporotic patients undergoing bisphosphonate treatment. Incidents of osteonecrosis of the jaw, known as bisphosphonate-related osteonecrosis of the jaw(BRONJ), have been reported in persons using bisphosphonates and undergoing invasive dental implants. Many studies show that the risk for bisphosphonateinduced osteonecrosis may be influenced by the route of drug administration, the potency and duration of use, as well as other local and systematic factors. This study reviews the risk factors of bisphosphonates that affect bone implants, the pharmacological effects of bisphosphonates, how bisphosphonates lead to implant failure, and how to control BRONJ.
