Mechanical stress plays an important role in the remodeling of bone. Stress can regulate the differentiation and function of osteoblasts and osteoclasts through a variety of signaling pathways, so as to achieve a balance of bone metabolism. Osteoblasts are regarded as the main cells participating in the formation of alveolar bone in stomatology. Early responses of osteoblasts to mechanical stress mainly depend on: Cell-cell communication, gap junctions, calcium ion signal pathway and fluid shear stress, etc.. This article summarized the early responses of osteoblasts to mechanical loading.
