The appearance and development of miniscrew anchorage system has greatly enriched orthodontic anchorage patterns and broadened the treatment scope, and abundance of knowledge has been accumulated along with its application. Meanwhile, the accompanying negative effects in treatment have aroused clinicians’ attention. This review was thereby to address the negative effects in clinical application of miniscrew anchorage, namely micro -movement under load, unwanted tooth movement, increased root absorption risk and irregular alveolar bone formation.