Oral and maxillofacial trauma in the sports games occurs frequently. As a protective appliance to avoid or reduce oral and maxillofacial trauma, mouthguard(MG) can significantly reduce the frequency and severity of orofacial injuries. However, MG are not generally used by athletes, the effect of protecting from injury is not widely known neither; moreover, the problems associated with using MG are discomfort, interference to pronunciation, breathing and sport performance during competition or training. This review provided reference for MG promotion and fabrication by describing the materials, design, application status and research progress of MG.