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论文摘要

克鲁宗综合征临床常用的手术方法和进展

Commonly used surgical methods and progress in clinical treatment of Crouzon syndrome

作者:刘兰 张凯亮 杨兰

Author:Liu Lan, Zhang Kailiang, Yang Lan

收稿日期:2013-03-28          年卷(期)页码:2013,40(6):790-794

期刊名称:国际口腔医学杂志

Journal Name:International Journal of Stomatology

关键字:克鲁宗综合征,手术方法,基因治疗,进展,

Key words:Crouzon syndrome,surgical method,gene therapy,advances,

基金项目:

中央高等学校基本科研基金资助项目(Lzujbky-2012-161)

中文摘要

克鲁宗综合征是一种颅缝早闭所致的常染色体显性遗传性疾病,表现为尖头畸形,面孔异常,如面中部凹陷和眼球突出等。针对此疾病的治疗方法有手术治疗、物理治疗和基因治疗等,其中以手术治疗为主要手段并针对各种不同的并发症治疗。手术治疗只能作为克鲁宗综合征治疗的一种补救措施,未来能否在胚胎发生期通过基因技术检测克鲁宗综合征,通过药物预防和阻断克鲁宗综合征的发生是临床研究的重点。本文就克鲁宗综合征治疗的手术时机和常用的外科治疗方法等研究进展作一综述。

英文摘要

Crouzon syndrome is an autosomal dominant hereditary disease caused by craniosynostosis that is characterized by hypsicephaly and facial abnormalities such as surface central sag and exophthalmos. Treatment mainly includes surgery, physical therapy, and gene therapy. In particular, surgery is the primary treatment modality and it can be used for a variety of complications. Currently, surgical treatment is merely a remedy for Crouzon syndrome. Future clinical research will determine whether Crouzon syndrome can be diagnosed during embryonic development through gene technology, as well as preventing and blocking the occurrence of Crouzon syndrome through medical treatment. This paper reviews the progress on the surgical timing and treatment methods for Crouzon syndrome.

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