WNT signal is involved in embryonic development. It is mainly involved in cell proliferation, differentiation, polarization, apoptosis, and anti-apoptosis. Recently, it has become the focus of many research. Cleft lip and palate are the major congenital malformations, and their pathogenesis is unclear. The WNT signal has been shown to have a close relationship with cleft lip and palate. This review summarized the research progress of WNT signal and its relation with cleft lip and palate.
