牙周膜干细胞的研究进展
Research progress on periodontal ligament stem cell
作者：鲁少文 税艳青
Author：vLu Shaowen, Shui Yanqing
收稿日期：2013-04-23 年卷（期）页码：2013,40(6):769-772
期刊名称：国际口腔医学杂志
Journal Name：International Journal of Stomatology
关键字：牙周组织工程, 牙周膜干细胞, 挑战, 展望,干细胞,牙周组织再生,牙周膜,
Key words：periodontal tissue engineering, periodontal ligament stem cell, challenge, pros,stem cell,periodontal tissue regeneration,periodontal ligament,
基金项目：
中文摘要
牙周病是一种由菌斑微生物引起的慢性感染性疾病，可引起牙周支持组织的破坏和丧失，最终导致牙齿松动脱落。牙周病治疗的最终目标是修复和重建受损的牙周支持组织。从牙周膜中分离获取的间充质干细胞具有成体干细胞的特性及多重分化潜能，可以分化为骨组织和牙周支持组织等多种类型的组织，这对牙周组织修复再生和牙周组织工程具有重大意义，因而备受关注。本文就牙周膜干细胞、牙周膜干细胞的生物学特性、牙周膜干细胞的影响因素及其调控机制等研究进展作一综述。
英文摘要
Periodontitis is a chronic inflammatory disease caused by dental plaque biofilm. It is a disease of the periodontium characterized by irreversible loss of connective tissue attachment and supporting alveolae, which may result in tooth loss. The aim of therapy is to regenerate the destroyed connective tissue attachment and supporting alveolae. Mesenchymal stem cells obtained from periodontal ligament are multipotent cells. These cells proliferate and differentiate into different types of tissues. Thus, mesenchymal stem cells are valuable for periodontal regeneration and periodontal tissue engineering. This review provides an overview of periodontal ligament stem cells and discusses recent studies and research prospects.
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