The tooth development is a complicated process, including early embryonic tooth position, tooth formation, and periodontal tissue maturation. Tooth development is actually the result of odontogenic mesenchymal interactions of the odontogenic epithelium and cranial neural crest cells. This process is affected by various signals. Yes-associated protein gene(YAP) is the target of the Hippo pathway, which can be detected in different tissues during the initial stage of tooth development. The Hippo-YAP signaling pathway regulates the balance between cell proliferation and programmed cell death by inhibiting YAP activity, thereby regulating the size of the organ. In this paper, we summarize the recent research progress on the Hippo-YAP signaling pathway and YAP expression during tooth development.
