The dental drug delivery system(DDDS), in combination with professional mechanical tooth cleaning and local application of drugs using trays, may be used as a physicochemical method to deliver drugs. The DDDS consists of individual trays called drug retainers that come in contact with the tooth surface and deliver drugs. The application maintains clinical efficacy and reduces altered taste, burning sensation, and drug-resistance in the mouth. The system can easily adjust the drugs and medication cycle. The treatment can be long or short, and removing the drugs can be convenient. Patients can wear their own trays at home or in the office, and they need not set up appointments. The tray fabrication, method of application, and current application of DDDS in tooth bleaching, treatment of periodontal disease, treatment of dentine hypersensitivity, and prevention of dental caries are reviewed in this article.
