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论文摘要

普萘洛尔在婴幼儿头颈部血管瘤中的应用

Treatment of infantile haemangioma in the head and neck region with propranolol

作者:王伟财综述 侯劲松审校

Author:Wang Weicai, Hou Jinsong.

收稿日期:2012-01-15          年卷(期)页码:2012,39(6):814-817

期刊名称:国际口腔医学杂志

Journal Name:International Journal of Stomatology

关键字:普萘洛尔,婴幼儿血管瘤,头颈部,

Key words:propranolol,infantile haemangioma,head and neck,

基金项目:

广东省自然科学基金资助项目(10151008901000025);广东省科技计划基金资助项目(2009B050700024,2009B060700096)

中文摘要

婴幼儿血管瘤(IH)是婴幼儿常见的良性肿瘤之一,60%发生于头颈部。IH 具有自限性,但是仍有10%的婴幼儿需要治疗。目前临床上常用的治疗方法包括激素治疗、干扰素治疗、硬化治疗、激光治疗等,但均存在一定不足或不良反应。近来,普萘洛尔被证明对增生期血管瘤具有明显的消退作用。本文就普萘洛尔治疗血管瘤的分子机制、临床应用、不良反应等相关问题进行简要综述。

英文摘要

Infantile haemangioma is a kind of the commonest childhood tumours and frequently occured in the head and neck region. They have a self-limiting course, but approximately 10% lesions require various treatment. Current clinical treatment include systemic or intralesional corticosteroids, vincristine, alpha-interferon, sclerotherapy, laser, or comprehensive of these therapies. Recent reports have highlighted the impressive efficacy of propranolol in treating rapidly proliferating haemangioma. This review focuses on the molecule mechanism of propranolol to treatment of haemangioma, clinical application and adverse respones.

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