Metastasis is the main cause of death in the patients with cancers, which is associated closely with cellular proliferation and invasion. The overexpression of phospholipase C-γ1 can increase the ability of cancerous cells to invade and metastasize, so it maybe a therapeutic potential to counteract the metastatic dissemination. This paper reviewed the literatures about the significance of phospholipase C-γ1 in the motility of cells, increasing the ability of cancerous cells to invade and metastasize, and the mechanisms of tumor migration and invasion.
