Tannins, which are extracted from oak bark to produce leather, widely exist in the plant kingdom and exhibit various physiological properties, such as bacteriostatic, antivirus, antitumor, antioxidation, mucous membrane protection, hemostasis and convergence. Tannins can inhibit cariogenic bacteria growth and adhesion, check the ability for acid production, and decrease glucosyltransferase activity. Tannins can induce the protein to coagulate, whereas the toxic effects attenuate lipopolysaccharide by dental pulp cells. Tannins can also reduce micro-leakage, improve the success rate of root canal therapy to complement the prognosis, and provide good protection and pulp teeth pulpotomy after trauma. The application of tannin on gingivitis and periodontal disease treatment is good because it can significantly reduce herpetic stomatitis and oral ulcer pain, promote ulcer healing, and simultaneously prevent and treat oral and maxillofacial trauma, trauma infection, promote scald, burns, and burn wound healing. Notably, tannins can enhance the immune function of inhibiting tumor growth, inducing tumor cell apoptosis, and reducing the risk of tumors of the skin and other organs.
