The tissue engineering scaffolds with nanostructures are now in widespread use in the research of guided tissue regeneration（GTR）, because of the good biocompatibility of the scaffolds and their capacity as the vector of bioactive substances. And how to incorporate the gene into the nanofibrous scaffolds is also an important research field in GTR. This paper reviewed the synthesis and characteristics of the nanofibrous scaffolds, the synthesis of gene modified electrospun nanofibrous membrane, and the study on the way gene was incorporated into and released from the nanofibrous scaffolds. The importance and manner of incorporating gene into the nanofibrous scaffolds and the application prospect of nanofibrous scaffolds were also outlined.
