Scaffolds are a key element of bone tissue engineering technology. The macro-structure and micro-structure are directly related to the biocompatibility of scaffolds. Changes in the structure directly affect the overall performance of scaffolds. This paper reviews the scaffold surface roughness, surface energy, aperture, connection diameter, porosity, vascularization, surface modification and composite materials, nanotechnology, and the structural changes affecting seed cell adhesion, proliferation, and differentiation on the scaffold.
