The mandibular nerve is an important factor of dental implant in the posterior area of the mandible. Dental implants in the posterior area of the mandible with abnormal mandibular nerve development are rarely observed in the clinic. A patient with missing C1, C2, C5, C6, and D1, D4 to D6 nerves, abnormal development of mandibular nerve under C5 and C6, and porcelain restorations in the opposite jaw is presented in this case. Combined with the clinical and literature data, the implant plan and the effect of restoration were discussed.