Helicobacter pylori(H.pylori) can remain in dental plaques, saliva, oral mucosa, and other parts of the oral cavity. H.pylori is mainly found in dental plaques, the gingival sulcus, and periodontal pockets. It is closely associated with not only periodontitisbut also oral mucosal diseases. Although H.pylori promotes or causes periodontitis, interestingly, it can also be eliminated through the infection caused byperiodontitis. However, subgingival H.pylori may be a source of H.pylori re-infection. The elimination rate of H.pyloriis lower in patients with deep periodontal pockets than in those with shallow pockets. H.pylori re-infection not only leads to oral diseases, such asperiodontitis, but also affects H.pylori treatment. Oral H.pylori may be related to recurrence of gastrointestinal diseases. Triple therapy combined with periodontal treatment can greatly improve the removal rate of H.pylori compared with simple triple therapy only. Daily plaque control combined with professional handling is more strategic for oral plaque control. H.pylori, its associated oral diseases, and treatment methods are reviewed in this paper.