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论文摘要

微小RNA在口腔扁平苔藓中的作用

Function of microRNAs in oral lichen planus

作者:刘佳佳 吴圆琴 曾昕 周瑜

Author:Liu Jiajia, Wu Yuanqin, Zeng Xin, Zhou Yu.

收稿日期:          年卷(期)页码:2015,42(1):48-53

期刊名称:国际口腔医学杂志

Journal Name:International Journal of Stomatology

关键字:微小RNA,自身免疫性疾病,口腔扁平苔藓,

Key words:microRNA,autoimmune diseases,oral lichen planus,

基金项目:

国家自然科学基金(81470747,81102060);高等学校博士学科点专项科研基金(20110181120068,20110181110055)

中文摘要

微小RNA家族在调控基因表达中的重要作用日益受到关注,其调控的基因涉及细胞增殖、凋亡、生长、分化和代谢、血管化和免疫应答等多种生物过程,其表达谱和表达量的变化与多种疾病如肿瘤、炎症性疾病、自身免疫性疾病的发生、发展密切相关。本文对口腔扁平苔藓中微小RNA的研究现状作一综述。

英文摘要

MicroRNAs(miRNAs) have attracted increasing attention because of their important roles in regulating gene expression. Gene regulation by miRNAs is involved in various biological processes, such as cell proliferation, apoptosis and metabolism, growth, differentiation, vascularization, and immune response. The expression spectrum and changes of miRNAs are closely related to the occurrence and development of various diseases, such as tumor, inflammatory diseases, and autoimmune diseases. This article reviews the current research statuses of miRNAs in oral lichen planus.

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