Peri-implantitis is an inflammatory process that affects the tissues around a functioning osseointegrated implant, resulting in loss of supporting bone, failure of osseointegration, and even loss of the implant. The incidence rate of peri-implant inflammation is about 4%-15%. Interleukin, a multi-functional cytokine involved in inflammatory reactions and immune responses around oral implants, performs an important function in the occurrence and development of periimplantitis. Blockage of soluble interleukin receptors offers great potential for treating peri-implantitis. A study of the immunoregulatory functions of interleukin is greatly significant for understanding the pathogenic mechanism and clinical treatment of peri-implantitis. This study aims to describe advances on the study of peri-implant tissues, the major risk factors of peri-implantitis, and the significance of interleukin in gingival crevicular fluid.
