Objective This study aimed to investigate the clinical value of cognitive behavioral intervention therapy on orthodontic treatment for adolescents. Methods A total of 120 adolescent orthodontic patients were selected and randomly categorized into experimental and control groups. Patients in the experimental group received orthodontic treatment combined with cognitive behavior intervention therapy, whereas those in the control group were administered with orthodontic treatment only. Results Patients in the experimental group demonstrated more active cooperation, better effect, lower rate of recurrence, and higher overall satisfaction compared with those in the control group. The two groups were significantly different. Conclusion Cognitive behavioral intervention therapy positively affects orthodontic treatment for adolescent patients, and thus, should be promoted in clinical applications.