Objective To study the effects of silane and titanate coupling agents as well as the dosage effects of enhanced polymethylmethacrylate(PMMA) on the mechanical properties of nano SiO2. Methods After using the mass fractions of 1%, 2%, 3%, 4%, and 5% of silane and titanate coupling agents on the surface modification of nano SiO2, the nano SiO2 was treated by adding 3% PMMA. Then, the standard module was created, the control group was untreated, and the three-point bending experiment was performed. Finally, hardness, friction, and wear were tested. Results The optimal dosages of silane and titanate coupling agents were measured at 2% and 3% respectively. Conclusion In a certain concentration range of nano SiO2, two modified coupling agents can improve the mechanical strength of denture base resins. The optimal dosage of the silane coupling agent is 2%, while that of the titanate coupling agent is 3%.