Objective This study aimed to explore the physical growth and development status of patients with cleft lip and palate and the difference of normal physical growth and development. Methods A total of 500 cleft lip and palate patients younger than 18 years old, including infants, young children, preschool children, school-age children, and adolescent children(100 cases each), were included in this study. The weight, height(length), head circumference, body mass index(BMI), intake, and abdominal skin fold of patients were observed. Results A total of 18 infants, 24 young children, 45 preschool children, 23 school-age children, and 25 adolescent children showed stunted growth. Conclusion The physical growth of patients with cleft lip and palate is commonly retarded, especially that of the preschool children. In addition, the physical measurement of cleft lip and palate children did not meet the requirement. In preschool children, the most important item to measure is the weight. By contrast, in school-age children, the height is the most important item to measure.