Objective To discussion the methods and clinical efficacy of first repair surgery according to the lip nasal contour line design of unilateral cleft lip. Methods Use of contour line affected side lip nasal to design cleft lip to surgery operative incision and comprehensive repair for lip nasal deformity of 196 patients with first stage unilateral cleft lip, include:1) operation incision line design in the lip nasal contour line curved, overlapping and bend contours, easily concealed; 2) fully stripping of abnormal attachment tissue deformity; 3) affected side alar cartilage and mucosal inward, outward and downward rotation of the medial foot of alar cartilage, correction of deformities of alar cartilage; 4) the lip muscle overlap or mattress suture reconstruction affected side philtrum crest height; 5) keeping the integrity of philtrum crest skin. Observation of postoperative nasal lip effect and symmetry. Results Patients with ipsilateral upper lip shape, lip peak length, nostril size, the morphology of nasal columella, nose shape and nasal base collapse degree, were significantly improved compared with preoperative, nose and lip shape close to normal shape, postoperative contour line of the scar is not obvious, plastic effect satisfaction. Conclusion According to the lip nasal contour line design and comprehensive repair of unilateral cleft lip, can achieve good appearance effect.