Nickel-titanium(NiTi) rotary instruments are widely used because of their short preparation time and minimum procedural errors. However, NiTi instruments should form a contact with irrigating solutions during cleaning and sterilization; as a result, their mechanical properties are significantly affected. The effects of the fatigue resistance of NiTi instruments influenced by different solutions have been extensively investigated. This review introduces the mechanisms of contact of NiTi instruments with media. This review also describes experimental design results.