Mg-based scaffold, as a novel biodegradable metallic material that inherently offers suitable mechanical properties and osteoconductivity, is proven safe in medical science. Mg-based scaffolds, including scaffolds with surface modification, Mg alloy scaffolds, and porous Mg scaffolds, can reduce corrosion, enhance the proliferation and adhesion of bone marrow stem cells, and promote angiogenesis. In animal models, Mg-based scaffolds can improve bone healing. Thus, these Mg-based scaffolds can potentially be applied to bone tissue engineering.