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论文摘要

镁基支架及其在动物骨缺损修复中的应用

Research progress on the Mg-based material scaffolds and its application in animal bone tissue engineering

作者:郑健茂 毛学理 凌均棨

Author:Zheng Jianmao, Mao Xueli, Ling Junqi.

收稿日期:2014-12-07          年卷(期)页码:2015,42(6):720-723

期刊名称:国际口腔医学杂志

Journal Name:International Journal of Stomatology

关键字:镁基材料,生物可降解金属材料,骨组织工程,支架,

Key words:Mg-based materials,biodegradable metallic materials,bone tissue engineering,bracket,

基金项目:

中文摘要

镁基是一种可降解金属材料,具有较好的生物相容性,其生物力学性能与骨组织相匹配,可在体内逐渐降解并由新生骨质取代,可促进细胞的黏附增殖,诱导骨生成,促进新骨生成,作为植入材料应用于医学的安全性高。镁基支架主要有表面改性的磷酸钙涂层镁基支架和聚合物膜镁基支架以及镁合金支架和多孔状镁基支架,其抗腐蚀性能高,可促进成骨细胞和骨髓间质干细胞的黏附和增殖,促进血管生成和营养物质的输送,有效降低镁合金的降解速度。在动物骨缺损修复方面,有明显的促进骨生长的作用,具有明显的诱导动物机体新骨生成的能力。综上所述,镁基支架在骨组织工程中的应用具有广阔的前景。

英文摘要

Mg-based scaffold, as a novel biodegradable metallic material that inherently offers suitable mechanical properties and osteoconductivity, is proven safe in medical science. Mg-based scaffolds, including scaffolds with surface modification, Mg alloy scaffolds, and porous Mg scaffolds, can reduce corrosion, enhance the proliferation and adhesion of bone marrow stem cells, and promote angiogenesis. In animal models, Mg-based scaffolds can improve bone healing. Thus, these Mg-based scaffolds can potentially be applied to bone tissue engineering.

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