核苷酸结合寡聚化结构域样受体热蛋白结构域亚家族成员3炎症小体的活化调节与牙周疾病的关系
Nucleotide-binding oligomerization domain-like-receptor family pyrin domain-containing 3 inflammasomes and the relationship between it and periodontal diseases
作者：吴冷 王骏 赵蕾 吴亚菲
Author：Wu Leng, Wang Jun, Zhao Lei, Wu Yafei.
收稿日期：2014-12-02 年卷（期）页码：2015,42(6):710-714
期刊名称：国际口腔医学杂志
Journal Name：International Journal of Stomatology
关键字：炎症小体,核苷酸结合寡聚化结构域样受体热蛋白结构域亚家族成员3,半胱氨酸天冬酰胺特异蛋白酶-1,白细胞介素,牙周疾病,免疫炎症反应,
Key words：inflammasomes,nucleotide-binding oligomerization domain-like-receptor family pyrin domain-containing 3,cysteinylaspartale specific protease-1,interleukin,periodontal disease,immunoinflammatory responses,
基金项目：
国家自然科学基金（81371150）；教育部留学回国人员科研启动基金（2013-693-11-11）
中文摘要
核苷酸结合寡聚化结构域样受体热蛋白结构域亚家族成员（NLRP）3炎症小体是一种位于细胞质内的多蛋白质复合体，由其核心成分感知病原体和宿主危险信号后组装而成，通过激活半胱氨酸天冬酰胺特异蛋白酶-1致促炎因子白细胞介素（IL）-1β成熟与分泌参与免疫炎症反应。牙周病是由宿主和微生物因素相互作用导致的局部炎症反应，而IL-1β又是牙周炎发病的关键因素之一。IL-1β的成熟和分泌与NLRP3炎症小体密切相关，且牙周致病菌可调节该炎症小体的表达及活化，因此NLRP3炎症小体对牙周疾病的发生发展和治疗具有重要意义。本文就NLRP3炎症小体的生物学功能、活化机制及其在牙周病学领域的研究进展作一综述。
英文摘要
The nucleotide-binding oligomerization domain-like-receptor family pyrin domain-containing(NLRP)3 inflammasome is an intracellular multi-protein complex that is assembled after its central component, NLRP3, and senses pathogens and host danger signals. The NLRP3 inflammasome induces maturation and secretion of inflammatory cytokines interleukin(IL)-1β by activating cysteinyl aspartale specific protease-1, thereby participating in immunoinflammatory responses. Periodontal diseases are caused by local immunoinflammatory responses against periodontal pathogens, with IL-1β being one of the critical factors. Furthermore, the processing and secretion of IL-1β is closely related to the NLRP3 inflammasome. Periodontal pathogens can regulate expression and activation of NLRP3 inflammasome. Therefore, NLRP3 inflammasome is significant to the development and treatment of periodontal diseases. This article focuses on the biological function and activation mechanism of the NLRP3 inflammasome and the relevant research progress on periodontal diseases.
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