Erbium:yttrum-aluminum-garnet laser(Er:YAGL), which is mainly based on the thermal effect, was used to treat dentin hypersensitivity. Laser affects the sensitive parts of the teeth and elevates temperature. Organic compounds on the surface of dentinal tubules become denatured and solidified, and then dentinal tubules become occluded. The fluidity of the liquid in the tube is reduced, consequently leading to a desensitizing effect. Laser irradiation alters the nerve fiber membrane permeability of sodium and potassium ions. It exerts an analgesic effect, where in the action potential in nerve endings increases and excitability reduces. Er:YAGL exhibits favorable antibacterial and hemostatic effects, increases the acid resistance of dentin, and minimizes injury. Er:YAGL can elicit good short-term and long-term effects. Given its accuracy and rapid onset, Er:YAGL is being widely used to improve the hypersensitivity of single tooth, multiple teeth, or even full mouth. Compared with neodymium:yttrium-aluminum-garnet laser and CO2 laser, Er:YAGL laser has better hygroscopicity and can effectively ablate dentin and enamel. Therefore, the application of Er:YAGL to alleviate dentin hypersensitivity is a relevant concern. This article reviews the mechanism and features of Er:YAGL.