DNA methylation disorders may increase the risk of human cancer. Research on DNA hypermethylation of cancer-related genes in oral squamous cells is relatively extensive; such research is based on detection via methylationspecific polymerase chain reaction and centered on healthy mucosa-associated tissues, as well as tumor tissue adjacent to carcinoma, to determine early diagnosis and malignant transformation. Research on oral squamous cell carcinoma generally focuses on the level of genomic DNA methylation using high-throughput detection technology. The expression levels of DNA methylation were obtained from healthy mucosa and precancerous lesions on squamous cell carcinoma. The results of this work provide a solid foundation for subsequent studies on the methylation of candidate genes.
