HIPPO signaling pathway is a highly conservative signaling pathway involved in the regulation of cell proliferation, apoptosis, and organ sizes. This pathway is involved in human growth and development and is closely related to the occurrence of various diseases. Herein, we review the recent progress of research on HIPPO pathway in the dental field and the influence of HIPPO pathway on the development of the oral system and diseases. This review can provide new ideas and strategies for further investigations and treatment of oral diseasesh.