Non-surgical technique is the basis of periodontal disease treatments, including scaling and root planning(SRP) and loose teeth fixation. This technique is suitable for patients with periodontal diseases and is the first step of the treatment protocol. Drug therapy is an auxiliary method for treatment of periodontal diseases. The treatment course of the disease is divided into antibiotics and immune regulatory drugs. Antibiotics are classified based on drug delivery routes into systemic or topical. Although traditional SRP presents several limitations, it is more effective than new techniques using periodontal endoscope, laser, and photodynamic therapy. In this paper, research progress on nonsurgical treatment for periodontal diseases is reviewed.