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论文摘要

微小RNA-203的生物学功能及其在口腔疾病中的作用

Biological functions of microRNA-203 and its role in oral diseases

作者:耿奉雪,潘亚萍

Author:Geng Fengxue, Pan Yaping.

收稿日期:          年卷(期)页码:2016,43(6):685-689

期刊名称:国际口腔医学杂志

Journal Name:International Journal of Stomatology

关键字:微小RNA-203,肿瘤,炎症,抑癌基因,炎症微环境,

Key words:microRNA-203,tumor,inflammation,tumor suppressor gene,inflammation micro-environment,

基金项目:

中文摘要

微小RNA-203(miR-203)具有多种生物学功能,可在不同水平调控下游基因的表达,参与肿瘤和炎症的形成和进展,是肿瘤早期诊断和预后判断的可靠分子标志物及治疗靶点。随着对炎症微环境下肿瘤形成机制的深入研究,miR-203调节炎症相关肿瘤的机制成为新的研究热点。近年来,miR-203在口腔疾病中的作用引起了学者的关注,本文就miR-203的生物学功能,miR-203与口腔疾病的关系等研究进展作一综述。

英文摘要

MicroRNA-203(miR-203) plays important roles in the development and progression of tumor and inflammation by targeting and regulating various downstream mediators at different levels. MiR-203 is a novel diagnostic and prognostic marker because of its therapeutic potential. The intensive investigation of mechanism in tumor development within micro-environment of inflammation has made the potent role of miR-203 in regulating inflammation-related tumor a new controversial issue. Recently, the regulatory mechanisms of miR-203 have been investigated in oral diseases. This mini-review focuses on the biological function of miR-203, especially its role in oral diseases.

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