Pulp calcification is one of important factors that make root canal preparation difficult. The pathogency is not clear. Many factors could promote its progression, including age, trauma and microorganisms and so on. Diagnosis methods usually include X-ray radiography, cone beam computer tomography, observation under an operative microscope and histologic sections. Applying an operative microscope and ultrasonic together in dealing with calcified canals during root canal treatment could raise the success rate. This paper reviews the causes, influence factors, diagnosis and treatment methods of pulp calcification.