Currently, the main treatment of pulp necrosis and apical periodontitis in immature permanent teeth with open apex is apexification, which has the high rate in root fracture in prognosis. Recently, with the success cases of the regenerative endodontics gradually increased, more patients were willing to receive it. About 35 papers, 92 cases and reports were collected and analyzed. The progress of regenerative endodontics applied in clinical treatment was summarized in this paper.
