Insufficient bone mass is a common problem in oral implant prostheses. The widely used bone regeneration methods in clinical applications include autologous bone grafting and the use of biological bone powder and platelet-rich fiber membrane. Despite the variations in all the methods, the clinical effects are unremarkable. Bones involve a dynamic organization mediated by osteoclast and osteoblast metabolism, which is influenced by various systemic factors. Calcitonin gene related peptides(CGRP) are extensively distributed neuropeptides in the body. Many studies have shown that CGRP plays an important role in bone metabolism, especially in osteogenesis. However, the specific mechanism of CGRP in osteogenesis is unclear and requires further investigation and discussion. Therefore, we conducted this review to study the role and mechanism of CGRP.
