ObjectiveThis study demonstrates subtotal maxillary reconstruction using one vascularized fibular osteomyocutaneous flap segment through the modified lateral lip-submandibular approach.MethodsEleven patients who were suffering from subtotal maxillary defects and who underwent maxillary reconstruction using one vascularized fibular osteomyocutaneous flap segment through modified lateral lip-submandibular approach were reviewed.ResultsHealing courses were uneventful in all cases; furthermore, acceptable maxillomandibular relationship, mouth opening, and speech were assessed as normal in all cases. No long-term functional limitation of the lower limb was reported even though all complained of big toe dysfunction, which eventually developed to a claw toe deformity. Other complications, such as diplopia, ectropion, facial paralysis, and sensory numbness in the lower lip, did not occur.ConclusionSubtotal maxillary reconstruction using one vascularized fibular osteomyocutaneous flap segment through the modified lateral lip-submandibular approach is a feasible and acceptable technique because of multiple advantages.