Acellular dermal matrix(ADM) is produced by a progress that removed cell component and preserved the dermis, which reserved properties of extracellular matrix and retained structural architecture. With good histocompatibility, ADM could be applied to restore tissue defect and guide tissue regeneration. Studiesin vitro,in vivoand clinical trials showed that ADM had been widely used in medicine as a repair material. This review summarized the progress of ADM on the properties, mechanisms and applications in periodontology.