肠道微生物调控骨代谢的研究进展
Research progress on gut microbiota regulating bone metabolism
作者：吴琪, 刘程程, 郑黎薇, 李继遥, 周学东, 徐欣
Author：Wu Qi, Liu Chengcheng, Zheng Liwei, Li Jiyao, Zhou Xuedong, Xu Xin
收稿日期：2016-12-26 年卷（期）页码：2017,44(6):628-635
期刊名称：国际口腔医学杂志
Journal Name：International Journal of Stomatology
关键字：肠道,微生物群落,骨代谢,牙槽骨,牙周炎,
Key words：gut,microbiota,bone metabolism,alveolar bone,periodontitis,
基金项目：国家自然科学基金（81430011,81371135）; 四川大学优秀青年学者基金（2015SCU04A16）
中文摘要
人类胃肠道内栖居着数量众多且种类繁杂的微生物群,肠道菌群稳态的维持对于宿主正常代谢活动的有序进行至关重要。随着人体微生物组研究的开展,肠道菌群变化对骨代谢活动的影响引起众多学者的关注。本文对肠道微生物与骨健康的关系、肠道微生物影响骨代谢的潜在机制以及肠道微生物对牙槽骨可能发挥的调控作用进行综述,以期为肠道微生物与骨代谢相关疾病的病因学研究以及疾病诊疗提供新的思路。
英文摘要
Heterogeneous microbiota dwells in the human gastrointestinal tract, and the maintenance of gut microbiota homeostasis plays an important role in normal host metabolism. With advancement in studies on human microbial communities, the effects of gut microbiota on bone metabolism have been extensively investigated. This review summarizes the research progress on the association between gut microbiome and bone metabolism and focuses on the relationship between gut microbiota and bone fitness, the potential mechanisms of mutual interactions, and the relationship between intestinal microbiota and alveolar bones. Research advancement in this field not only enhances our understanding of the etiological role of gut microbiota in bone metabolism-related diseases but also possibly provides a novel approach for the management of bone diseases involving the microbiota.
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